Product Description

GTPase Kras Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: E-AB-40639-50, E-AB-40639-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: KRAS

Target Synonym: KRAS; KRAS2; RASK2; GTPase Kras; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase Kras

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P01116

Background: KRAS, also called p21, is a member of the Ras superfamily of proteins. It is located on human chromosome 12, and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family, the KRAS protein is a GTPase, and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.

Concentration: 2.5mg/ml

Immunogen: Recombinant Human KRAS protein expressed by E.coli.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Purification Method: Antigen Affinity Purification

Dilution: WB 1:1000-1:2000

Calculated MW: 21 kDa

Observed MW: 21 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only