HIF1α Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11945-20, A11945-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 83 kDa/93 kDa/96 kDa
Observed Molecular Weight: 120 kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 3091
SWISS: Q16665
Alternate Names: HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha; HIF1α
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:2500 - 1:5000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Invasion and Metastasis, Signal Transduction, mTOR Signaling Pathway, Cell Biology Developmental Biology, Autophagy, Endocrine Metabolism, Nucleotide metabolism, Warburg Effect, Cardiovascular, Angiogenesis, Hypoxia.
NCBI Alias: HIF1A
Research Use Only