Product Description

HNF-3α/β/γ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4054-50, ES4054-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: FOXA1, HNF3A, TCF3A, Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, Forkhead box protein A1, Transcription factor 3A, TCF-3A, FOXA2, HNF3B, TCF3B, Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA3, HNF3G, TCF3G, Hepatocyte nuclear factor 3-gamma, HNF-3-gamma, HNF-3G, Fork head-related protein FKH H3, Forkhead box protein A3, Transcription factor 3G, TCF-3G

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human FOXA1 around the non-acetylation site of Lys265. AA range:231-280

Isotype: IgG

Target: HNF-3α/β/γ

Specificity: HNF-3α/β/γ Polyclonal Antibody detects endogenous levels of HNF-3α/β/γ protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in prostate and ESR1-positive breast tumors, Overexpressed in esophageal and lung adenocarcinomas,

Observed Band (KD): 50kD

Function: Function: Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes
Online Information: Hepatocyte nuclear factors entry,Similarity: Contains 1 fork-head DNA-binding domain

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: FOXA1/FOXA2/FOXA3

Protein Name: Hepatocyte nuclear factor 3-alpha/Hepatocyte nuclear factor 3-beta/Hepatocyte nuclear factor 3-gamma

Mouse Gene ID: 15375

Mouse SwissProt Number: P35582

Rat Gene ID: 25098

Rat SwissProt Number: P23512

Research Use Only