Product Description

HNF-4α (Acetyl Lys106) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8628-50, ES8628-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)

Clonality: Polyclonal

Immunogen: Synthetic Acetyl peptide from human protein at AA range: 106

Isotype: IgG

Target: HNF4α

Specificity: The antibody detects endogenous HNF-4α when Acetyl occurs at Lys106

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Kidney, Liver,

Observed Band (KD): 55kD

Fields: AMPK signaling pathway, Maturity onset diabetes of the young

Function: Alternative Products: Additional isoforms seem to exist,Disease: Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM: 125850], also shortened MODY-1. MODY [MIM: 606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications
Function: Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine
Miscellaneous: Binds fatty acids
Online Information: Hepatocyte nuclear fac

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: HNF4A HNF4 NR2A1 TCF14

Protein Name: Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)

Mouse SwissProt Number: P49698

Rat SwissProt Number: P22449

Research Use Only