Product Description

HOME1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9745-50, ES9745-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: HOME1

Specificity: HOME1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Frontal cortex, Pancreas, Stomach mucosa, Synovial cell,

Observed Band (KD): 38kD

Fields: FoxO signaling pathway, Glutamatergic synapse

Function: Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development
Similarity: Belongs to the Homer family
Similarity: Contai

Subcellular Location: Cytoplasm Cell junction, synapse, postsynaptic density Cell junction, synapse Cell projection, dendritic spine Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum

Storage and Stability: -20°C/1 year

Gene Name: HOMER1 SYN47

Protein Name: Homer protein homolog 1 (Homer-1)

Mouse SwissProt Number: Q9Z2Y3

Rat SwissProt Number: Q9Z214

Research Use Only