Product Description

HSP105 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2580-50, ES2580-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.,PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.,similarity:Belongs to the heat shock protein 70 family.,subunit:Interacts with HSPA8/HSC70.,tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: HSPH1, HSP105, HSP110, KIAA0201, Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human HSP105. AA range:791-840

Isotype: IgG

Target: HSP105

Specificity: HSP105 Polyclonal Antibody detects endogenous levels of HSP105 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in testis, Present at lower levels in most brain regions, except cerebellum, Overexpressed in cancer cells,

Observed Band (KD): 100kD

Fields: Protein processing in endoplasmic reticulum

Function: Function: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities
PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity
Similarity: Belongs to the heat shock protein 70 family
Subunit: Interacts with HSPA8/HSC70
Tissue Specificity: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: HSPH1

Protein Name: Heat shock protein 105 kDa

Mouse Gene ID: 15505

Mouse SwissProt Number: Q61699

Research Use Only