Product Description

HTR2C Polyclonal Antibody

Sizes: 120μL, 200μL

Catalogue Numbers: E-AB-90309-120, E-AB-90309-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HTR2C

Target Synonym: HTR2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P28335

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human HTR2C

Buffer: PBS with 0.02% sodium azide, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000

Calculated MW: 28kDa/51kDa

Observed MW: 75kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only