Human CD45RA Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A24839-20, A24839-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Category: Polyclonal Antibodies
Applications: IF-P
Cross-reactivity: Human
Protein Weight: 130kDa/147kDa
Observed Molecular Weight: Refer to figures
Immunogen: Synthetic peptide .
Species: Human
GeneID: 5788
SWISS: P08575
Alternate Names: PTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; receptor-type tyrosine-protein phosphatase C; Human CD45RA
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: IF-P, 1:50 - 1:200
Research Areas: Signal Transduction, Kinase, Tyrosine kinases, Cell Biology & Developmental Biology, Apoptosis, Immunology & Inflammation, CD markers, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway, Neuroscience, Cell Type Marker, Stem Cells, Hematopoietic Progenitors, Microglia marker.
NCBI Alias: PTPRC
Research Use Only