IDO1 Rabbit PolymAb®
Sizes: 20μL, 100μL
Catalogue Numbers: A1614PM-20, A1614PM-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes indoleamine 2, 3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Category: Monoclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human
Protein Weight: 45kDa
Observed Molecular Weight: 45kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 3620
SWISS: P14902
Alternate Names: IDO; INDO; IDO-1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:3000 - 1:18000 IF/ICC, 1:200 - 1:800 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Amino acid metabolism, Immunology Inflammation, Cardiovascular.
NCBI Alias: IDO1
Research Use Only