Product Description

IFN-α/βRα Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5837-50, ES5837-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: IHC, IF, ELISA

Alternate Names: IFNAR1, IFNAR, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Interferon-alpha/beta Receptor alpha chain. AA range:436-485

Isotype: IgG

Target: IFN-α/βRα

Specificity: IFN-α/βRα Polyclonal Antibody detects endogenous levels of IFN-α/βRα protein.

Dilution: WB 1:500-2000,Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells, Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1, Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R, Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R,

Molecular Weight (Da): 64kD

Fields: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer

Function: Function: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves
PTM: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase
Sequence Caution: Contaminating sequence. Potential poly-A sequence
Similarity: Belongs to the type II cytokine receptor family
Similarity: Contains 3 fibronectin type-III domains
Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R, isoform 1 is not expressed in U266R

Subcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein Late endosome Lysosome Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes

Storage and Stability: -20°C/1 year

Gene Name: IFNAR1

Protein Name: Interferon alpha/beta receptor 1

Mouse SwissProt Number: P33896

Research Use Only