Product Description

Ihh Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3753-50, ES3753-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: IHH, Indian hedgehog protein, IHH, HHG-2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Ihh. AA range:209-258

Isotype: IgG

Target: Ihh

Specificity: Ihh Polyclonal Antibody detects endogenous levels of Ihh protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in embryonic lung, and in adult kidney and liver,

Observed Band (KD): 45kD

Fields: Hedgehog signaling pathway, Proteoglycans in cancer

Function: Disease: Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM: 607778]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles
Disease: Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM: 112500]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short
Function: Intercellular signal essential for a varie

Subcellular Location: [Indian hedgehog protein N-product]: Cell membrane, Lipid-anchor, Extracellular side The N-terminal peptide remains associated with the cell surface, [Indian hedgehog protein C-product]: Secreted, extracellular space The C-terminal peptide diffuses from the cell, Cell membrane

Storage and Stability: -20°C/1 year

Gene Name: IHH

Protein Name: Indian hedgehog protein

Mouse Gene ID: 16147

Mouse SwissProt Number: P97812

Research Use Only