Product Description

IKB-α (S32/S36) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0634-50, AP0634-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that resμlts in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resμlting Rel-dependent transcription are activated by a highly diverse group of extracellμlar signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, IHC

Alternate Names: NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, IKBA, MAD4, NFKBI

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human IKB-α.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IKB-α (S32/S36) polyclonal antibody detects endogenous levels of IKB-α protein.

Molecular Weight: ~ 36 kDa

Pathway: Regμlation of Apoptosis, Death Receptor Signaling, MAPK Erk in Growth and Differentiation Pathway(, Inhibition of Apoptosis, NF-kB Signaling, Phospholipase Signaling, T cell receptor signaling, Toll-like Receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P25963

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only