Product Description

IKB-ε (D17) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1191-50, BS1191-100

Sizes: 50µl, 100µl

Swiss-Prot: O00221

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: IkB-ε (I-kappa-B-epsilon), also known as NFKBIE (NFκB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFκB inhibitor family. Localizing to the cytoplasm, IkB-ε is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-ε inhibits c-Rel and NFκB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-ε undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IκB-ε (D17) polyclonal antibody detects endogenous levels of IκB-ε protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of IkB-ε (D17) polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: PC12 cell lysate, Immunohistochemistry (IHC) analyzes of IKB-ε (D17) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: NF-kappa-BIE; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon; NFKBIE; IKBE; IkB ε; IkBε

Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human IKB-ε.

Conjugate: Unconjugated

Modification: Unmodified