Product Description

IL-10 (3-8) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66505-50, BS66505-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregμlation and inflammation. It down-regμlates the expression of Th1 cytokines, MHC class II Ags, and costimμlatory molecμles on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regμlation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregμlator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Mouse

Applications: WB

Alternate Names: IL-10, Cytokine synthesis inhibitory factor (CSIF), Interleukin-10

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human IL-10.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from cell cμlture supernatant by protein A+G and the purity is > 95% (by SDS-PAGE).

Specificity: IL-10 (3-8) monoclonal antibody detects endogenous levels of IL-10 protein.

Molecular Weight: ~ 21 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22301

Product: Mouse IgG, 0.6mg/ml in PBS with 0.05% Proclin300, 50% glycerol, 0.2% BSA, pH7.2.

Research Use Only