Product Description

IL-10 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20585-50, RA20585-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: interleukin 10 (IL10) Homo sapiens The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC-p, IF/ICC, ELISA

Alternate Names: IL10, Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Molecular Weight: 20

Protein Molecular Weight (kDa): 20

Storage: -20°C/1 year

Human Gene ID: 3586

Human SwissProt Number: P22301

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only