Product Description

IL-12A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5894-50, ES5894-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: IL12A, NKSF1, Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35, NK cell stimulatory factor chain 1, NKSF1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human IL-12A. AA range:16-65

Isotype: IgG

Target: IL-12A

Specificity: IL-12A Polyclonal Antibody detects endogenous levels of IL-12A protein.

Dilution: Western Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Placenta,

Observed Band (KD): 25kD

Fields: Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Alcoholic liver disease, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Pathways in cancer, Inflammatory bowel disease, Allograft rejection, Lipid and atherosclerosis

Function: Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
Online Information: Interleukin-12 entry,Similarity: Belongs to the IL-6 superfamily
Subunit: Heterodimer with IL12B, disulfide-linked. The heterodimer is known as interleukin IL-12

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: IL12A

Protein Name: Interleukin-12 subunit alpha

Mouse Gene ID: 16159

Mouse SwissProt Number: P43431

Rat Gene ID: 84405

Rat SwissProt Number: Q9R103

Research Use Only