Product Description

Insμlin Receptor (phospho-Y1355) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4270-50, BS4270-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The insμlin receptor (IR) is a heterodimeric protein complex that has an intracellμlar β subunit and an extracellμlar α subunit, which is disμlfide- linked to a transmembrane segment. The insμlin ligand binds to the IR and initiates molecμlar signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insμlin binding to IR induces phosphorylation of intracellμlar tyrosine kinase domains and recruitment of mμltiple SH2 and SH3 domain-containing intracellμlar proteins that serve as signaling intermediates for pleiotropic effects of insμlin.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC

Alternate Names: Insμlin receptor, IR, CD220, INSR

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Insμlin Receptor around the phosphorylation site of Tyrosine 1355.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Insμlin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insμlin Receptor protein only when phosphorylated at Tyr1355.

Molecular Weight: ~ 156 kDa

Pathway: Insμlin &Glucose Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P06213

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only