Integrin β1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90724-50, BS90724-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P05556
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, IHC FC
All Applications: WB:1:500-1:1,000
FC:1:100
IHC:1:200
Background: Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). Integrins are obligate heterodimers containing two distinct chains, called the α (alpha) and β (beta) subunits. The molecular mass of the integrin subunits can vary from 90?kDa to 160?kDa. Beta subunits have four cysteine-rich repeated sequences. Both α and β subunits bind several divalent cations. Integrins have two main functions: Attachment of the cell to the ECM and signal transduction from the ECM to the cell. However, they are also involved in a wide range of other biological activities, including immune patrolling, cell migration, and binding to cells by certain viruses, such as adenovirus, echovirus, hantavirus, and foot and mouth disease viruses. Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.
Purification and Purity: Peptide affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Integrin β1 polyclonal antibody detects endogenous levels of Integrin β1 protein.
Bioworld Molecular Weight: 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of CD29 on different cell lysates using anti-CD29 antibody at 1/1000 dilution.
Positive control:
Lane 1: Human liver
Lane 2: Human kidney
Lane 3: NIH/3T3
Lane 4: A172
Lane 5: Hela, Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti-CD29 antibody. Counter stained with hematoxylin.
Alternative Name: GPIIA, ITB1, beta1 integrin, CD29, Fibronectin receptor subunit beta, FNRB, Glycoprotein IIa, GP IIa, GPIIA, Integrin beta-1, integrin VLA-4 beta subunit, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), ITB1, ITGB1, MDF2, MSK12, OTTHUMP00000019420, Very late activation protein, beta polypeptide, VLA BETA, VLA-4 subunit beta, VLA-BETA, VLAB, VLAbeta,
Immunogen: peptide
Conjugate: Unconjugated
Modification: Unmodified