Integrin β4 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90727-50, BS90727-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P16144 (Human) A2A863(Mouse)
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, IHC
All Applications: WB:1:1,000-1:2,000
IHC:1:50-1:200
Background: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Integrin β4 (ITGB4), also known as CD104, is a 1,822 amino acid single-pass type I membrane protein belonging to the Integrin β chain family. Known to associate with Integrin α6, Integrin β4 functions as a receptor for Laminin and is predominantly expressed by epithelia. Integrin β4 exists as five alternatively spliced isoforms that are encoded by a gene located on human chromosome 17q25.1.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Integrin β4 polyclonal antibody detects endogenous levels of Integrin β4 protein.
Bioworld Molecular Weight: 210 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Integrin beta 4 on Jurkat cells lysates using anti-Integrin beta 4 antibody at 1/500 dilution.
Positive control: Line 1: A431 Line 2: A549, Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Integrin beta 4 antibody. Counter stained with hematoxylin.
Alternative Name: ITGB4, CD 104, CD104, CD104 antigen, gp150, Integrin beta 4 subunit, Integrin beta-4, ITB4, ITG B4, ITGB 4, Itgb4,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified