Product Description

INTS2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6911-50, ES6911-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A, MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1, MIM 180680) and U2 (RNU2, MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: INTS2, KIAA1287, Integrator complex subunit 2, Int2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human INTS2. AA range:201-250

Isotype: IgG

Target: INTS2

Specificity: INTS2 Polyclonal Antibody detects endogenous levels of INTS2 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Testis,

Observed Band (KD): 140kD

Function: Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the Integrator subunit 2 family
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12

Subcellular Location: Nucleus membrane, Single-pass membrane protein Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: INTS2

Protein Name: Integrator complex subunit 2

Mouse Gene ID: 70422

Mouse SwissProt Number: Q80UK8

Research Use Only