JNK1/2/3 (phospho Tyr185) Polyclonal Antibody - RA20850

JNK1/2/3 (phospho Tyr185) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20850-50, RA20850-100

Citations, Manuals and MSDS Available upon request.

Background: mitogen-activated protein kinase 8 (MAPK8) Homo sapiens The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Alternative Names: MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi

Applications: IF/ICC; WB; IHC-p; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5599/5601/5602

Protein MW (KDa): 45

SWISS: P45983/P45984/P53779

Source: Rabbit

Research Use Only