Kaiso Recombinant Rabbit mAb Sizes: 50μl, 100μl Catalogue Numbers: BS46685-50, BS46685-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: This gene encodes a transcriptional regμlator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α, 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010] Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB Alternate Names: ZNF348, ZNF-kaiso Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: A synthetic peptide of human Kaiso Dilution: WB: 1:1000-1:5000 Purification: Affinity Purification Specificity: IgG Molecular Weight: 90 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q86T24 Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. Research Use Only