[KD Validated]PHOX2B Rabbit pAb - A21990

[KD Validated]PHOX2B Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A21990-20, A21990-100

Citations, Manuals and MSDS Available upon request.

Background: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Mouse

Protein Weight: 32kDa

Observed Molecular Weight: 37kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 8929

SWISS: Q99453

Alternate Names: CCHS; PMX2B; NBLST2; NBPhox; PHOX2B

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Signal Transduction, Neuroscience.

NCBI Alias: PHOX2B

Research Use Only