[KO Validated] Cytokeratin 8 Rabbit pAb - A24434

[KO Validated] Cytokeratin 8 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A24434-20, A24434-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB

Cross-reactivity: Human, Mouse

Protein Weight: 54 kDa/56 kDa

Observed Molecular Weight: 54 kDa

Immunogen: Synthetic peptide .

Species: Human

GeneID: 3856

SWISS: P05787

Alternate Names: K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; 8

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000

Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Intermediate Filaments.

NCBI Alias: KRT8

Research Use Only