(KO Validated) HIRA Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-62250-60, E-AB-62250-120, E-AB-62250-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: HIRA
Target Synonym: HIRA; DGCR1; TUP1; TUPLE1
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: WB, IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P54198
Background: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human HIRA (NP_003316.3).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000 IHC 1:100-1:200
Calculated MW: 89kDa/111kDa
Observed MW: 112kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only