[KO Validated] HP1 alpha/CBX5 Rabbit pAb - A12577

[KO Validated] HP1 alpha/CBX5 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A12577-20, A12577-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, ELISA

Cross-reactivity: Human, Mouse

Protein Weight: 22kDa

Observed Molecular Weight: 22kDa

Immunogen: Recombinant protein (or fragment)

Species: Human

GeneID: 23468

SWISS: P45973

Alternate Names: HP1; HP1A; HEL25; X5

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling.

NCBI Alias: CBX5

Research Use Only