Product Description

[KO Validated] Insμlin-degrading enzyme (IDE) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6849-50, BS6849-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a zinc metallopeptidase that degrades intracellμlar insμlin, and thereby terminates insμlins activity, as well as participating in intercellμlar peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insμlin resμlts in insμlin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellμlar space, cell membrane, peroxisome, and mitochondrion. Alternative splicing resμlts in mμltiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF/ICC

Alternate Names: IDE, INSμlYSIN

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human Insμlin-degrading enzyme (Insμlin-degrading enzyme (IDE))(NP_004960.2).

Dilution: WB, 1:500 - 1:2000 IF/ICC, 1:10 - 1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 118kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14735

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only