[KO Validated] LITAF Rabbit pAb - A5469

[KO Validated] LITAF Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A5469-20, A5469-100

Citations, Manuals and MSDS Available upon request.

Background: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD) . Multiple alternatively spliced transcript variants have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, IP, ELISA

Cross-reactivity: Human, Mouse

Protein Weight: 17kDa

Observed Molecular Weight: 23kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 9516

SWISS: Q99732

Alternate Names: PIG7; SIMPLE; TP53I7; AF

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Growth factors.

NCBI Alias: LITAF

Research Use Only