[KO Validated] MSH2 Rabbit pAb - A21494

[KO Validated] MSH2 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A21494-20, A21494-100

Citations, Manuals and MSDS Available upon request.

Background: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, IP, ELISA

Cross-reactivity: Human, Rat

Protein Weight: 105kDa

Observed Molecular Weight: 105kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 4436

SWISS: P43246

Alternate Names: FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2; H2

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, Cancer, Tumor suppressors, Cell Biology Developmental Biology, Apoptosis.

NCBI Alias: MSH2

Research Use Only