[KO Validated] MTA2 Rabbit pAb - A2243

[KO Validated] MTA2 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A2243-20, A2243-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Category: Polyclonal Antibodies

Applications: WB, ELISA, ChIP

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 75kDa

Observed Molecular Weight: 75kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 9219

SWISS: O94776

Alternate Names: PID; MTA1L1; A2

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 5μg antibody for 10μg-15μg of Chromatin

Research Areas: Epigenetics Nuclear Signaling, Chromatin Remodeling.

NCBI Alias: MTA2

Research Use Only