[KO Validated] TMED10 Rabbit pAb - A18090

[KO Validated] TMED10 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A18090-20, A18090-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, IF/ICC, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 25kDa

Observed Molecular Weight: 21kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 10972

SWISS: P49755

Alternate Names: p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24 (DELTA) ; 10

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Signal Transduction, Cell Biology Developmental Biology, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease.

NCBI Alias: TMED10

Research Use Only