Product Description

Lambda 5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4368-50, ES4368-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: immunoglobulin lambda like polypeptide 1(IGLL1) Homo sapiens The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: IGLL1, IGL1, Immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1, CD179b

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGLL1. AA range:151-200

Isotype: IgG

Target: Lambda 5

Specificity: Lambda 5 Polyclonal Antibody detects endogenous levels of Lambda 5 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative),

Observed Band (KD): 23kD

Fields: Primary immunodeficiency

Function: Disease: Defects in IGLL1 are a cause of autosomal recessive non-Bruton type agammaglobulinemia [MIM: 601495]. It is characterized by agammaglobulinemia and markedly reduced numbers of B cells
Online Information: IGLL1 mutation db,Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain
Subunit: Associates non-covalently with VPREB1
Tissue Specificity: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative)

Subcellular Location: Endoplasmic reticulum Secreted In pre-B cells, localizes predominantly to the endoplasmic reticulum

Storage and Stability: -20°C/1 year

Gene Name: IGLL1

Protein Name: Immunoglobulin lambda-like polypeptide 1

Mouse Gene ID: 16136

Mouse SwissProt Number: P20764

Research Use Only