LDL Receptor (LDLR) Rabbit pAb - A21806

LDL Receptor (LDLR) Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A21806-20, A21806-100

Citations, Manuals and MSDS Available upon request.

Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, IF/ICC, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 95kDa

Observed Molecular Weight: 100-160kDa

Immunogen: Synthetic peptide .

Species: Human

GeneID: 3949

SWISS: P01130

Alternate Names: FH; FHC; FHCL1; LDLCQ2; LDL Receptor (LDLR)

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Lipid Metabolism, Cholesterol Metabolism, Cardiovascular, Heart, Lipids, Cardiovascular diseases, Heart disease.

NCBI Alias: LDLR

Research Use Only