Product Description

LDLRAD1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61636-50, BS61636-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Low-density lipoprotein receptor class A domain-containing protein 1, belonging to the Low-density lipoprotein receptor class A domain-containing protein family.LDLRAD1 and LDLRAD2 function as recetor, LDLRAD3 may influence APP processing, resμlting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production, LDLRAD3 functions as a negative regμlator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellμlar matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellμlar signal transducer and transcriptional modμlators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regμlate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellμlar signal.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Low-density lipoprotein receptor class A domain-containing protein 1, LDLRAD1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human LDLRAD1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: LDLRAD1 polyclonal antibody detects endogenous levels of LDLRAD1 protein.

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q5T700

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only