Product Description

LIM and SH3 domain Protein 1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8817-50, ES8817-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human LIM and SH3 domain protein 1. at AA range: 90-130

Isotype: IgG

Target: LIM and SH3 domain protein 1

Specificity: This antibody detects endogenous levels of LIM and SH3 domain protein 1

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Epithelium, Liver, Mammary carcinoma, Platelet, Skin, T-cell,

Observed Band (KD): 38kD

Function: Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
PTM: Phosphorylated
Similarity: Contains 1 LIM zinc-binding domain
Similarity: Contains 1 SH3 domain
Similarity: Contains 2 nebulin repeats
Subcellular Location: Associated with the F-actin rich cortical cytoskeleton
Subunit: Interacts with F-actin

Subcellular Location: Cytoplasm, cell cortex Cytoplasm, cytoskeleton Associated with the F-actin rich cortical cytoskeleton

Storage and Stability: -20°C/1 year

Gene Name: LASP1 MLN50

Protein Name: LIM and SH3 domain protein 1

Mouse Gene ID: 16796

Mouse SwissProt Number: Q61792

Research Use Only