Product Description

M-CSF Receptor (phospho-Tyr546) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14991-50, ES14991-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human M-CSF Receptor (Tyr546)

Isotype: IgG

Target: M-CSFR

Specificity: This antibody detects endogenous levels of Human Mouse M-CSF Receptor (phospho-Tyr546)

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in bone marrow and in differentiated blood mononuclear cells,

Observed Band (KD): 107kD

Fields: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Osteoclast differentiation, Hematopoietic cell lineage, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia

Function: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Function: Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
Similarity: Contains 1 protein kinase domain
Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
Subunit: Interacts with INPPL1/SHIP2 and THOC5
Tissue Specificity: Expressed in bone marrow and in differentiated blood mononuclear cells

Subcellular Location: Cell membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CSF1R FMS

Protein Name: M-CSF Receptor (Tyr546)

Mouse Gene ID: 12978

Mouse SwissProt Number: P09581

Rat SwissProt Number: Q00495

Research Use Only