Product Description

Macroglobulin α-2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4098-50, ES4098-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: A2M, CPAMD5, FWP007, Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human A2M. AA range:871-920

Isotype: IgG

Target: Macroglobulin α-2

Specificity: Macroglobulin α-2 Polyclonal Antibody detects endogenous levels of Macroglobulin α-2 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Secreted in plasma,

Observed Band (KD): 170kD

Fields: Complement and coagulation cascades

Function: Developmental Stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Online Information: Alpha-2 macroglobulin entry,Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family
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Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: A2M

Protein Name: Alpha-2-macroglobulin

Research Use Only