Product Description

MAG Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4247-50, ES4247-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: MAG, GMA, Myelin-associated glycoprotein, Siglec-4a

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG. AA range:501-550

Isotype: IgG

Target: MAG

Specificity: MAG Polyclonal Antibody detects endogenous levels of MAG protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494), Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494), Detected in compact myelin (at protein level) (PubMed:6200494), Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552),

Observed Band (KD): 70kD

Fields: Cell adhesion molecules

Function: Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid
Online Information: Siglec-4,Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains
Subunit: Binds to RTN4R

Subcellular Location: Cell membrane, Single-pass type I membrane protein Membrane raft

Storage and Stability: -20°C/1 year

Gene Name: MAG

Protein Name: Myelin-associated glycoprotein

Mouse Gene ID: 17136

Mouse SwissProt Number: P20917

Rat Gene ID: 29409

Rat SwissProt Number: P07722

Research Use Only