Product Description

MAL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9835-50, ES9835-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 70-150

Isotype: IgG

Target: MAL

Specificity: MAL Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Lung, Lymphocyte, Placenta,

Observed Band (KD): 16kD

Function: Developmental Stage: Expressed in the intermediate and late stages of T-cell differentiation
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function
PTM: Lipoprotein
Similarity: Belongs to the MAL family
Similarity: Contains 1 MARVEL domain

Subcellular Location: Membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: MAL

Protein Name: Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein)

Mouse SwissProt Number: O09198

Rat SwissProt Number: Q64349

Research Use Only