MALT1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2144-20, A2144-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12) . This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t (11;18) (q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3 (API2) -MALT1], and a t (14;18) (q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1) . Alternatively spliced transcript variants have been described for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 92kDa
Observed Molecular Weight: 102kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 10892
SWISS: Q9UDY8
Alternate Names: MLT; MLT1; IMD12; PCASP1; MALT1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Caspases, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway.
NCBI Alias: MALT1
Research Use Only