Product Description

MAP2 Mouse Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: EM1067-50, EM1067-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

Reactivity: Human, Rat, Mouse

Host: Mouse

Applications: IHC

Alternate Names: MAP2A, MAP2B, MAP2C

Clonality: Monoclonal

Immunogen: Synthetic Peptide

Isotype: IgG1

Dilution: IHC 1:200

Concentration: 1mg/mL,

Subcellular Location: Cytoplasm, cytoskeleton

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Research Use Only