Product Description

MARCH1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20645-50, RA20645-100

Citations, Manuals and MSDS Available upon request.

Background: membrane associated ring-CH-type finger 1 (MARCH1) Homo sapiens MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19) . MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]) .[supplied by OMIM, Mar 2010],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171

Applications: IHC-p; IF (paraffin section) ; WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 55016

Protein MW (KDa): 32

SWISS: Q8TCQ1

Source: Rabbit

Research Use Only