Product Description

MARK4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6934-50, ES6934-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: microtubule affinity regulating kinase 4(MARK4) Homo sapiens This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IF, ELISA

Alternate Names: MARK4, KIAA1860, MARKL1, MAP/microtubule affinity-regulating kinase 4, MAP/microtubule affinity-regulating kinase-like 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MARK4. AA range:461-510

Isotype: IgG

Target: MARK4

Specificity: MARK4 Polyclonal Antibody detects endogenous levels of MARK4 protein.

Dilution: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Isoform 2 is brain-specific (PubMed:11326310), Expressed at highest levels in brain and testis, Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945),

Observed Band (KD): 83kD

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily
Similarity: Contains 1 KA1 (kinase-associated) domain
Similarity: Contains 1 protein kinase domain
Similarity: Contains 1 UBA domain
Tissue Specificity: Ubiquitous. Isoform 2 is brain-specific

Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm Cell projection, dendrite Localized at the tips of neurite-like processes in differentiated neuroblast cells Detected in the cytoplasm and neuropil of the hippocampus

Storage and Stability: -20°C/1 year

Gene Name: MARK4

Protein Name: MAP/microtubule affinity-regulating kinase 4

Mouse Gene ID: 232944

Mouse SwissProt Number: Q8CIP4

Research Use Only