Product Description

MEK-4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2774-50, ES2774-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: MAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated pro

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human SEK1/MKK4. AA range:46-95

Isotype: IgG

Target: MEK-4

Specificity: MEK-4 Polyclonal Antibody detects endogenous levels of MEK-4 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Abundant expression is seen in the skeletal muscle, It is also widely expressed in other tissues,

Observed Band (KD): 44kD

Fields: MAPK signaling pathway, ErbB signaling pathway, Toll-like receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, GnRH signaling pathway, Relaxin signaling pathway, Growth hormone synthesis, secretion and action, Alcoholic liver disease, Epithelial cell signaling in Helicobacter pylori infection, Salmonella infection, Yersinia infection, Chagas disease, Hepatitis B, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Chemical carcinogenesis - reactive oxygen species, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Function: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases
Similarity: Belongs to the protein kinase superfamily
Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily
Similarity: Contains 1 protein kinase domain
Subunit: Interacts with SPAG9
Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues

Subcellular Location: Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: MAP2K4

Protein Name: Dual specificity mitogen-activated protein kinase kinase 4

Mouse Gene ID: 26398

Mouse SwissProt Number: P47809

Research Use Only