Product Description

MEK4 (F194)Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: EA362-50, EA362-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction.

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1

Clonality: Polyclonal

Immunogen: Recombinant Protein

Isotype: IgG

Dilution: WB 1:1,000-2,000

Concentration: 1mg/mL,

Observed Band (KD): 44kDa

Subcellular Location: Cytoplasm, Nucleus

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Research Use Only