Product Description

MHC Class I Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS49342-50, BS49342-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecμle is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobμlin). The heavy chain is anchored in the membrane. Class I molecμles play a central role in the immune system by presenting peptides derived from the endoplasmic reticμlum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecμle. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jμl 2008]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, ICC/IF, FC, IP

Alternate Names: HLAA

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human MHC Class I

Dilution: WB: 1:1000 IHC: 1:1000 ICC/IF: 1:200 FC: 1:200 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 30-50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01889, P30443, P30499

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only