Product Description

MHC class I Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS66218-50, BS66218-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell surface proteins are responsible for the regμlation of antigen-specific immunity in humans. HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A,  B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in order to activate a cytotoxic T cell response. HLAs corresponding to MHC class II (HLA-DP,  DM,  DO,  DQ, and DR) present antigens from outside of the cell, approximately 15 to 24 residues in length, to CD4+ T helper cells, which in turn secrete cytokines and stimμlate B cells to produce antibodies to that specific antigen. HLAs corresponding to MHC class III encode components of the complement system.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: HLAA, HLA class I histocompatibility antigen, A-1 alpha chain, MHC class I antigen A*1, HLAB, HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLAA, HLA class I histocompatibility antigen, A-68 alpha chain, Aw-68, HLA class I histocompatibility antigen, A-28 alpha chain, MHC class I antigen A*68, HLAA, HLA class I histocompatibility antigen, A-2 alpha chain, MHC class I antigen A*2, HLAA, HLA class I histocompatibility antigen, A-11 alpha chain, MHC class I antigen A*11, HLAA, HLA class I histocompatibility antigen, A-30 alpha chain, MHC class I antigen A*30, HLAA, HLA class I histocompatibility antigen, A-26 alpha chain, MHC class I antigen A*26

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human MHC class I.

Dilution: WB, 1:500 - 1:1000

Purification: The antibody was affinity-purified from cell cμlture supernatant by protein A+G and the purity is > 95% (by SDS-PAGE).

Specificity: MHC class I Monoclonal Antibody detects endogenous levels of MHC class I protein.

Molecular Weight: ~ 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P30443, P01889, P01891, P01892, P13746, P16188, P30450

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only