Product Description

MK Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3907-50, ES3907-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: MDK, MK1, NEGF2, Midkine, MK, Amphiregulin-associated protein, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MDK. AA range:94-143

Isotype: IgG

Target: MK

Specificity: MK Polyclonal Antibody detects endogenous levels of MK protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in various tumor cell lines, In insulinoma tissue predominantly expressed in precancerous lesions,

Observed Band (KD): 18kD

Function: Function: Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development
Induction: By heparin and retinoic acid
Similarity: Belongs to the pleiotrophin family
Subunit: Homodimer

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: MDK

Protein Name: Midkine

Mouse SwissProt Number: P12025

Rat Gene ID: 81517

Rat SwissProt Number: Q9R1S9

Research Use Only