Product Description

MOAP1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11803-50, ES11803-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: modulator of apoptosis 1(MOAP1) Homo sapiens The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: MOAP1

Specificity: MOAP1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Widely expressed, with high levels in heart and brain,

Observed Band (KD): 38kD

Function: Domain: The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction
Function: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation
Similarity: Belongs to the PNMA family
Subunit: Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization
Tissue Specificity: Ubiquitously expressed with higher levels in heart and b

Subcellular Location: Cytoplasm, cytosol Mitochondrion outer membrane Extracellular vesicle membrane Forms virion-like extracellular vesicles that are released from cells

Storage and Stability: -20°C/1 year

Gene Name: MOAP1 PNMA4

Protein Name: Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)

Mouse SwissProt Number: Q9ERH6

Research Use Only