Product Description

MRP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9040-50, ES9040-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MARCKS like 1(MARCKSL1) Homo sapiens This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 1-80

Isotype: IgG

Target: MRP

Specificity: MRP Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Epithelium, Muscle,

Observed Band (KD): 21kD

Fields: Fc gamma R-mediated phagocytosis, Leishmaniasis

Function: Function: May be involved in coupling the protein kinase C and calmodulin signal transduction systems
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the MARCKS family

Subcellular Location: Cytoplasm, cytoskeleton Cell membrane, Lipid-anchor Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin Colocalizes with F-actin at the leading edge of migrating cells (By similarity) In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924)

Storage and Stability: -20°C/1 year

Gene Name: MARCKSL1 MLP MRP

Protein Name: MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)

Mouse SwissProt Number: P28667

Rat SwissProt Number: Q9EPH2

Research Use Only